The genus Ulva, commonly known as sea lettuce, is a widespread green macroalga with significant ecological and economic importance. In the Aegean Sea, various Ulva species, particularly in eutrophic, sheltered bays, exhibit distinct ecophysiological characteristics, making them promising candidates for cultivation. Successful cultivation requires clean starting material (biobanking) and optimizing temperature, light, and nutrient supply (phenotyping) to maximize growth and desired biochemical composition, mirroring the ecophysiological factors that govern its growth in natural habitats. How close are we to developing region-specific and tailored protocols for Ulva cultivation?